Different methods of caffeine exposure also have different effects on suckling pups during lactation. Suckling pups receive a much greater amount of caffeine through gavage or subcutaneous injection than through caffeine in the diet or caffeine dissolved in the drinking water of lactating dams…
An in vitro study has shown that toxic levels of caffeine (50 mg/ml) could have a prejudicial effect on the number of proliferating glial cells and on the increase of hyaluronan secretion per cell, which could affect myelination onset (Marret et al., 1993).
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