Diagnosis of Restless Legs Syndrome


Restless legs syndrome (RLS), like most syndromes, represents multiple biological pathologies that share a common clinical presentation. As such, the diagnosis of RLS relies almost entirely on the subjective report of symptoms matching the defining features of RLS. nonetheless, the nonspecific…

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PATHOPHYSIOLOGY: Circadian Rhythm of Restless Legs Syndrome


Circadian Variation in Restless Legs Syndrome
One of the defining features of the restless legs syndrome (RLS) is that it shows a notable circa-dian rhythm with symptoms intensifying later in the day. This holds true at least for those who have normal sleep-wake schedules. Those who do shift…

Does Poor Sleep Quality in Late Life Compromise Cognition and Accelerate Progression of the Degenerative Dementias?

Cycles of sleep and wakefulness begin in utero and persist throughout life. As such, sleep is both a personally familiar experience and a biologically essential activity. At the same time, the fundamental links between sleep, health, and disease remain elusive. Several decades of sleep research…