Affective Disorders – Neurobiological Models of Depression


In addition to the consideration of neurotransmitter function in depression, other hypotheses pose alternative neurobiological models that are now being tested. One such hypothesis, the glucocorticoid hypothesis, focuses on the stress-related neuroendocrine abnormalities that are frequently…

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Pharmacology of Adult Neurogenesis: Compensatory and Regenerative Processes

Neurogenesis occurs in the adult brain of mammals and is modulated by a broad range of stimuli and conditions. Drugs used in the treatment of Alzheimer’ s disease (AD) and depression stimulate neurogenesis in the adult hippocampus. Neurogenesis is enhanced in the brain of patients with…

Does Poor Sleep Quality in Late Life Compromise Cognition and Accelerate Progression of the Degenerative Dementias?

Cycles of sleep and wakefulness begin in utero and persist throughout life. As such, sleep is both a personally familiar experience and a biologically essential activity. At the same time, the fundamental links between sleep, health, and disease remain elusive. Several decades of sleep research…